The Effect of Anoac Topical Cream in the Treatment of Perianal Symptoms Due to Anal Fissure and Hemorrhoids

The purpose of this study was to evaluate the safety and efficacy of ANOAC topical cream in the management of perianal symptoms due to anal fissure and hemorrhoids. Adult patients with perianal symptoms were enrolled in the study. Patient applied Anoac cream twice a day for 60 days. Perianal symptoms like anal pain, swelling, itching, burning and pricking sensation were evaluated on the visual analog scale (VAS) and patient’s quality of life on SF-36 questionnaire. A total of 197 patients enrolled in the study out of which 135 (68.53%) were males and 62 (31.47%) were females. Mean age was 39.47 ±12.22. A significant (p<0.0001) reduction in anal pain from 8.06±2.17 to 0.28±0.74 and in burning sensation from 7.61 ± 2 00 to 0.18 ± 0.54 were observed at the end of the therapy. Also, there was significant reduction in pricking sensation from 1.44 ± 2.62 to 0.03 and swelling in the anal region from 1.65±2.83 to 0.05±0.32. On day 30 there were significant improvements in mean SF-36 scores over baseline in five items, while on day 60 there were improvements in all items over baseline, but not significant. There was no adverse event observed during the study and the therapy was well tolerated in all patients. Topical application of ANOAC cream demonstrated a significant beneficial effect when applied to patients suffering from perianal symptoms due to anal fissure and piles and also improved quality of life.